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Sometimes, toxic side effects aren't discovered until fairly late in the drug development process, when substantial amounts of time and money have already been invested in clinical trials.
New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations.
OPKO Health, Inc., has completed patient recruitment in the first phase 3 trial of Rayaldy to treat patients with secondary hyperparathyroidism, stage 3 or 4 chronic kidney disease and vitamin D insufficiency.
"Two more children have died in Cambodia of bird flu, bringing the number of fatal cases this year to four and the number of cases overall to five," the Associated Press/Wall Street Journal reports, noting only three cases were reported in all of 2012. "WHO says bird flu, also known as avian influenza, or H5N1, has killed 360 other people worldwide since surfacing in 2003," with most cases "linked to contact with infected poultry," the news agency writes.
Among children whose parents and other primary caregivers have limited English proficiency, there is an associated increased length of hospital stay and decreased number of home health care referrals for pediatric inpatients with infections requiring long-term antibiotics, according to a report in the May issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
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