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In this issue of the Journal of Clinical Investigation, Karen Avraham and colleagues at Tel Aviv University identified a genetic mutation in two families with hereditary high frequency hearing loss. The mutated gene, which has not previously been linked to hearing loss, encodes NESP4, a protein that is expressed in the outer nuclear membrane (ONM) of the hair cells of the ear.
A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.
The American Society for Radiation Oncology (ASTRO) has developed a guideline on the radiotherapeutic and surgical management for newly diagnosed brain metastases. It has been published in Practical Radiation Oncology (PRO), ASTRO's official clinical practice journal.
"[N]ew diagnostic techniques [for tuberculosis] need to be studied in children," according to a Lancet Infectious Diseases Reflection. "Tuberculosis is an important cause of morbidity and mortality in children worldwide, but estimates of disease burden are inaccurate because most cases are not confirmed," the author writes. He discusses a study published in the same issue that examines various methods for diagnosing TB in children.
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