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In one of the first genome-wide studies to hunt for both genes and their regulatory "tags" in patients suffering from a common disease, researchers have found a clear role for the tags in mediating genetic risk for rheumatoid arthritis (RA), an immune disorder that afflicts an estimated 1.5 million American adults.
When a parent takes an infant to the Children's Health Center in San Francisco for a routine checkup, a pediatrician will check the baby's vitals and ask how the child is doing at home.
The American Association for Cancer Research (AACR) and the Cancer Research Institute (CRI) will present Robert D. Schreiber, Ph.D., Alumni Endowed Professor of Pathology and Immunology, Professor of Molecular Microbiology, and Director of the Center for Human Immunology and Immunotherapy Programs at Washington University School of Medicine in St. Louis, Mo., with the second annual AACR-CRI Lloyd J. Old Award in Cancer Immunology at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.
Neural stem cells are responsible for the formation of differentiated daughter cells in the developing brain. If no new cells are needed, the stem cells may enter a resting phase called quiescence. Biologists at Johannes Gutenberg University Mainz have now discovered that the phases of quiescence in the Drosophila fruit fly central nervous system are controlled by the Hippo signaling pathway. Drosophila serves as a model organism that helps geneticists to decode the molecular fundamentals of cellular biology and unravel mechanisms that are conserved in human beings and other vertebrates.
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