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Researchers at Yale School of Medicine have found that new disease pathways involving more than one cell type leads to Type 1 Gaucher disease, a rare genetic disorder in which fatty substances called glycosphingolipids accumulate in cells, resulting in liver/spleen enlargement, osteoporosis, bone pain, and increased risk of cancer and Parkinson's disease.
Despite few successes to date, gene therapy is a highly promising approach for medical therapy in the future.
Staying clear of diseases requires that the proteins in our cells cooperate with one another. But, it has been a well-guarded secret how tens of thousands of different proteins find the correct dancing partners as they degrade and build up the human body, brain and nervous system.
Noting that the Bill & Melinda Gates Foundation and the U.K. government will co-host an international family planning summit in London in July, Gavin Yamey of the Global Health Group at the University of California, San Francisco; Craig Cohen, a professor of obstetrics, gynecology and reproductive services at the University of California; and Elizabeth Bukusi, chief research officer and deputy director of research and training at the Kenya Medical Research Institute, write in a BMJ commentary, "More than 120 million women worldwide aged 15-49 years have an unmet need for family planning, which is due a renaissance after years of neglect."
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