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A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.
Research published in the December 13, 2009 edition of Nature Structural Biology uncovers the structural basis for the multifunctionality of aminoacyl tRNA synthetases. Aminoacyl tRNA synthetases are universal and essential enzymes of protein synthesis machinery found in all organisms.
The prolonged periods of juvenility and nutritional dependence that are characteristic of human development are thought to facilitate brain and somatic growth in children, as well as provide opportunities to learn and accumulate skills required for a productive adult life. In chimpanzees, the benefits of continuing to associate with mothers after becoming nutritionally independent are less well understood.
Even though most adults want to avoid looking older than their actual age, research led by St. Michael's Hospital shows that looking older does not necessarily point to poor health. The study found that a person needed to look at least 10 years older than their actual age before assumptions about their health could be made.
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