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Patients fitted with an orthopedic prosthetic commonly experience a period of intense pain after surgery. In an effort to control the pain, surgeons inject painkillers into the tissue during the operation.
Despite a huge amount of research effort, the molecular mechanisms that underlie the transition from a "normal" cell to a cancerous cell are only poorly understood. After the discovery of the first cancer-causing genes or oncogenes and the finding that they are mutated forms of normal cellular genes, it was widely believed that a single mutation was enough to cause cancer.
Researchers at Roswell Park Cancer Institute (RPCI) have determined that cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CS/HIPEC), a complex procedure to treat advanced abdominal cancers, can be done safely, and may be an effective therapy for select patients. Study results are published in the June issue of Cancer Medicine.
A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication.
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