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Omeros Corporation today announced positive results from a Phase 2a clinical trial of OMS824, the company's phosphodiesterase 10 (PDE10) inhibitor, in which the drug was well tolerated and demonstrated comparable systemic pharmacokinetics when administered alone and concomitantly with approved antipsychotic agents in patients with schizophrenia. OMS824 selectively inhibits PDE10, an enzyme expressed in areas of the brain linked to a wide range of diseases that affect cognition, including schizophrenia and Huntington's disease.
Using gamma radiation to inactivate bacteria for the preparation of vaccines, instead of traditional heat or chemical methods of inactivation, appears to create a vaccine that is more effective than so-called "killed" vaccines against disease, and has the added advantage of a longer storage life than "live" vaccines.
Survival rates for patients with breast cancer have improved significantly in the last four decades, and many patients will eventually die from non-cancer-related causes.
The brains of males and females, and how they use them, may be far more different then previously thought, at least in the fruit fly Drosophila melanogaster, according to research funded by the Wellcome Trust.
Risk of suicide after self-harm; work stress in non-consultant hospital doctors; and monitoring and assessing the impact of the economic crisis on the Irish health system are among the research areas that will be explored by scholars of an innovative new PhD programme in population health and health services research.
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