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The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover - the skin, nails, bone marrow, lungs and gut. Patients with DKC experience life-threatening symptoms. Bone marrow failure increases their risk of fatal infections and cancer. Many die before the age of 30 and management of the disease is limited to trying to treat its symptoms.
Patients with bipolar disorder who are insulin resistant are likely to also be refractory to mood-stabilising treatment, report researchers.
The widespread use of a simplified clinical tool to estimate future coronary risk could lead to the classification of millions of Americans into different risk groups than when using the original, "gold-standard" tool. Millions of patients may have been misclassified into higher-risk groups and therefore potentially over-treated, while others may have ended up in lower-risk groups and therefore potentially under-treated for heart disease. The study-, led by William Gordon from Weill Cornell Medical College in the US and colleagues, is published in the Journal of General Internal Medicine-, published by Springer.
On Friday June 11th, Chief Judge Gregory Sleet of the United States District Court for the District of Delaware issued an important pre-trial ruling in the long-running patent dispute between SPI Pharma and Roquette Freres.
Mice who keep busy playing with toys also keep their brains and bodies active; more importantly, they also have lower levels of the peptides and brain plaques associated with Alzheimer's disease, compared to mice raised in environments not "enriched" with chew toys, running wheels,and tunnels, according to a new study in the 11 March issue of the journal Cell.
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