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Pfizer Inc. announced today that its 20-Valent Pneumococcal Conjugate Vaccine candidate, PF-06482077, received Breakthrough Therapy designation from the US Food and Drug Administration for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults aged 18 years and older. Pfizer expects to start Phase 3 trials in a few months.
Most testing is driven by fever, persistent cough of recent onset, and abnormalities in smell. Such symptoms are considered indicative of continuing SARS-CoV-2 infection, requiring quarantine of all such individuals until they test negative for the virus. This approach is justifiable in adults since fever and cough from other causes are rare in healthy adults.
Many hospitals, health centers, large physician groups, and insurers are working toward or considering forming ACOs, and physicians are being approached to participate. ... The CMS have implemented demonstration projects that incorporate the ACO concept, and several private payers have fielded their own versions of the idea. ... Medscape spoke to Anders M. Gilberg, senior vice president of Government Affairs, Medical Group Management Association.
A team of researchers led by Peter Calvert (SUNY Upstate Medical University) has, for the first time, measured the diffusion coefficient of a protein in a primary cilium and in other major compartments of a highly polarized cell. The study appears in the March issue of the Journal of General Physiology.
What makes cancer cells so dangerous is that they grow in an unregulated way and proliferate much faster than other cells. The proteasome, a large protein complex, plays a key role in this process: By breaking down used proteins for recycling, it clears the way for the next cycle.
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