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Understanding membrane protein crystallization is one of the main goals of molecular biology studies aimed at the structural characterization of proteins.
By combining stem cell science with orthopedic surgery, a team of researchers at the University of British Columbia and Vancouver Coastal Health Research Institute aims to reduce the 10 per cent failure rate in hip replacements and make repeat replacements and other joint repairs obsolete within 10-15 years.
Cells constantly swap cargo bound in vesicles, miniscule membrane-enclosed packages of proteins and other chemicals. Before the swap can take place, the vesicle membrane must fuse with another membrane, creating channels packages can pass through.
Dravet syndrome is a severe genetic epilepsy that appears early in life. About 75 percent of cases can be attributed to mutations in the SCN1A gene encoding the sodium channel NaV1.1. The remaining patients with this syndrome are without a definitive molecular genetic diagnosis. Research presented today at the American Epilepsy Society's 65th Annual Meeting has found a non-SCN1A candidate gene and suggests that Dravet syndrome may be caused by any one of a number of yet unidentified genes.
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