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Amid concerns about the rising number of new tuberculosis cases worldwide, researchers led by Rockefeller University's Seth A. Darst have reexamined and disproved a theory that describes how a potent class of antibiotics kills a deadly form of bacteria. The findings, which will appear in this week's online issue of the Proceedings of the National Academy of Sciences, not only bring scientists closer to understanding how these antibiotics work but also how the bacteria become resistant to their effects.
The emerging field of synthetic biology-designing new biological components and systems-is revolutionizing medicine.
"A proliferation of complex challenges to development, such as political conflict, economic austerity, and environmental degradation, all demand attention, but should not deflect from recognizing that good health is central to advancing global prosperity," GAVI Alliance CEO Seth Berkley, WHO Director-General Margaret Chan, Global Fund to Fight AIDS, TB and Malaria Executive Director Mark Dybul, World Bank Sector Manager for Health in Latin America Keith Hansen, UNICEF Executive Director Anthony Lake, UNFPA Executive Director Babatunde Osotimehin, and UNAIDS Executive Director Michel Sidibé, write in a Lancet opinion piece examining the post-2015 development agenda.
COPD is defined as a preventable and treatable disease associated with significant extrapulmonary consequences that may contribute to severity. The pulmonary component of COPD is characterised by airflow limitation that is not fully reversible. The airflow limitation is usually progressive with an abnormal inflammatory response of the lungs to noxious particles (GOLD Strategy Document). Airflow obstruction in COPD is not highly variable and largely irreversible.
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