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Scientists at the Virginia Bioinformatics Institute at Virginia Tech have constructed a mathematical and computational model of inflammatory bowel disease that allows researchers to simulate the cellular and molecular changes underlying chronic inflammation in humans. The model allows scientists to explore different interactions of cells in the immune system, check how these cells are linked to inflammation in the colon, and identify intervention points to perhaps stop the disease in its tracks.
The Hopkins team discovered that adding a single protein, dubbed BMP4, induced mouse stem cells to become fat cells. A very similar signal is likely to be involved in humans, too, say the scientists.
One of the most remarkable features of glioblastoma is the metabolic reprogramming of cancerous cells, resulting in uncontrolled cell proliferation, hypoxic conditions and angiogenesis.
Edimer Pharmaceuticals, a biotechnology company focused on developing an innovative therapy for the rare genetic disorder X-linked Hypohidrotic Ectodermal Dysplasia (XLHED), today announced the enrollment and completed dosing of the first XLHED-affected neonate in a Phase 2 trial of EDI200, the company's novel, proprietary, recombinant protein.
A recent report on reducing harm from alcohol by the Government's strategy unit has been 'neutered' in comparison with the same study's interim findings, according to an editorial in this week's BMJ.
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