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In a study published online today in Nature, a team of researchers from Penn State University and the University New South Wales present the complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and a Bantu from southern Africa, along with three additional whole exome sequences of Kalahari hunter-gatherers.
Triggered by decreases in ER Ca2+ level, conformational changes of the endoplasmic reticulum (ER) luminal domain in STIM1 would switch on its cytoplasmic domain (CT) to engage and gate ORAI channels on plasma membrane, resulting in Ca2+ influx.
Clinical Research Management, Inc. (ClinicalRM) – a full-service Contract Research Organization (CRO) providing services for basic and applied research, clinical trials, and regulatory support – announced today it was awarded a contract by the Department of Health and Human Services, National Institutes of Health, Division of Microbiology and Infectious Diseases (DMID) of the National Institute of Allergy and Infectious Diseases (NIAID).
In a study that could point the way toward a new strategy for treating patients after a heart attack, UCLA stem cell researchers led by associate professor of medicine (cardiology) and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Arjun Deb have discovered that some scar-forming cells in the heart, known as fibroblasts, have the ability to become endothelial cells (the cells that form blood vessels).
Disparities in cancer stage and treatment are the main reasons why Medicaid-insured and uninsured rectal cancer patients are twice as likely to die within five years as privately insured patients. That is the conclusion of a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. Because poorer survival among rectal cancer patients without private insurance is largely attributable to later cancer stage at diagnosis and inadequate treatment, disparities may be lessened through health care reform.
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