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Howard Hughes Medical Institute researchers have introduced a genetic mutation found in some patients with early onset Parkinson's disease into mice, creating a new animal model of the disease.
Neurological diseases including Parkinson's, Tourette's, attention deficit hyperactivity disorder (ADHD), Alzheimer's, and schizophrenia are all associated with alterations in dopamine-driven function involving the dopamine transporter (DAT).
Researchers from the Johns Hopkins Bloomberg School of Public Health have developed a test they say will allow them to test thousands of FDA-approved drugs to see if they will work against the bacteria that causes tick-borne Lyme disease.
Researchers have long wondered if medications could treat alcohol abuse. Ihsan Salloum, M.D., chief of the Division of Alcohol and Drug Abuse at the University of Miami Miller School of Medicine, hopes to answer that question in part with a new clinical trial with E. Sherwood Brown, M.D., Ph.D., at UT Southwestern Medical Center in Dallas.
In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)–associated renal cell carcinoma.
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