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For decades, scientists have thought the bacteria that cause the bubonic plague hijack host cells at the site of a fleabite and are then taken to the lymph nodes, where the bacteria multiply and trigger severe disease. But UNC School of Medicine researchers discovered that this accepted theory is off base. The bacteria do not use host cells; they traffic to lymph nodes on their own and not in great numbers.
Together with their multifaceted action mechanisms, activation-induced cytidine deaminase (AID) and so-called APOBEC proteins are important factors in the body's immune response and offer fast and effective protection against a large number of DNA and RNA viruses.
One change to field triage guidelines for emergency medical services responding to older adults with head trauma could make a "clinically important improvement over usual care," according to a study and accompanying editorial published earlier this month in Annals of Emergency Medicine ("Out-of-Hospital Triage of Older Adults With Head Injury: A Retrospective Study of the Effect of Adding 'Anticoagulation or Antiplatelet Medication Use' as a Criterion" and "Can an Out-of-Hospital Medication History Save Lives for Injured Older Adults?").
Saint Louis University researchers are studying how fetal exposure to inflammation can alter immune responses after birth.
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